Passages Serenity, Passages Replenishment, and Passages Replenishment Extreme

Immediately after withdrawal from chronic substance abuse, your body will almost always feel depleted, with symptoms ranging from decreased energy and anxiety to sleeplessness, cravings, and depression. Passages Dependency Cure nutritional supplement formulas help bring your body back into balance. These three naturally supportive formulas are specifically designed to assist the body in correcting neurotransmitter and nutritional imbalances associated with substance abuse, stress, insomnia, and depression. The formulas help calm nervousness, relieve stress, and boost your energy.

How do we "feel" good? We feel good when our body produces the feel-good neurotransmitters dopamine, seratonin, norepinepherine, GABA, epinephrine, and glutamate. Production of those neurotransmitters is literally the only way you can feel good. The substances you have been taking have been flogging your neurotransmitters into over-secreting, and that drug-forced over-secretion of neurotransmitters is responsible for the depletion. After withdrawal, it is the depletion of neurotransmitters that is one of the major causes of relapse. Passages Dependency Cure nutritional supplement formulas work to naturally replenish and rebalance the body's neurotransmitters.

Passages Serenity, Passages Replenishment, and Passages Replenishment Extreme are a 3-part program designed to provide natural assistance to correct neurotransmitter and nutritional imbalances associated with substance abuse as well as stress, insomnia, and depression.

Neurotransmitters are essential chemical messengers that regulate brain, muscle, nerve, and organ function. They transmit impulses throughout every system in your body and are responsible for how you feel and behave. They are the juices that are responsible for the function of all your organs, your brain, your thoughts, your muscles—everything. The most common neurotransmitters are serotonin, GABA, dopamine, norepinephrine, epinephrine, and glutamate. Low levels of these important chemicals are extremely common in people with poor lifestyle and diet, as is often the case in drug-dependent individuals.



Serotonin is synthesized from tryptophan, an amino acid found in food. Serotonin functions in the central nervous system as a neurotransmitter that modifies emotions. It has been found to play a key role in governing mood, aggression, anger, sleep, appetite, nausea, body temperature, sexual behavior, and metabolism.

GABA (Gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the central nervous system. The most crucial role GABA has is to balance excitability throughout the nervous system. It is also important in regulating muscle tone. When GABA activity is depressed, a number of psychiatric and neurological problems arise, including anxiety.



Dopamine is both a neurotransmitter and a hormone. It is known as the “reward neurotransmitter” because of its important functions in motivation, desire, and pleasure. Dopamine is found, like most neurotransmitters, in the brain and the neurons. Substance abuse depletes dopamine levels. Dopamine is biosynthesized in the body by nerve tissue, certain specific areas of the brain, and in the adrenal glands from L-tyrosine.

Epinephrine, or adrenaline, is also a neurotransmitter and a hormone. It is known as a catecholamine, which is a substance classified from the sympathetic side of the nervous system derived from the amino acids tyrosine and phenylalanine. Epinephrine is better known as the “flight or fight” hormone and plays a pivotal part in the effects of stress on the body in the face of addiction and stress.

Norepinephrine, or noradrenaline, also functions as a neurotransmitter and a hormone. Like epinephrine, it also is part of the “flight or fight” stress reaction process. In addition, it also affects the portions of the brain where attention is controlled. Norepinephrine is synthesized from dopamine in the adrenals and the nervous system.

Glutamate is the most plentiful excitatory neurotransmitter in the nervous system. It is important in cognitive activity such as memory and learning ability.

Those who have completed their withdrawal from addictive substances can benefit from these formulas. Nearly all people who have withdrawn from substance abuse have neurotransmitter and nutritional imbalances. The longer those large doses of addictive substances are taken, the greater the chemical imbalances. Using large doses for prolonged periods of time also causes adrenal fatigue accompanied by low levels of cortisol and other adrenal hormones.



Neurotransmitters are essential chemical messengers that regulate brain, muscle, nerve, and organ function. They transmit impulses throughout every system in your body and are responsible for how you feel and behave. They are the juices that are responsible for the function of all your organs, your brain, your thoughts, your muscles, everything. The most common neurotransmitters are serotonin, GABA, dopamine, norepinephrine, epinephrine, and glutamate. Low levels of these important chemicals are extremely common in people with poor lifestyle and diet, as is often the case in drug-dependent individuals. Neurochemical imbalances complicate the mental, emotional, and physical dysfunction of addiction, slowing the recovery process. Neurotransmitter imbalances are also commonly seen in people who are experiencing bulimia, anorexia, fibromyalgia, chronic fatigue, insomnia, chronic pain, menopause, or any condition that induces serious stress on their system.



Decreased energy, anxiety, sleep disturbance, cravings, and depression are symptoms of imbalances in neurotransmitters among those who have withdrawn from substances.



Passages has formulated this supplement program to address neurotransmitter imbalances and symptoms. The three formulas provide the body with the precursors, or building blocks, for the neurotransmitters that are depleted in addiction. Providing these precursors, essential vitamins, and cofactors to the body can increase the production of neurotransmitters and improve neurotransmitter levels. (Cofactors are things like B vitamins and minerals such as magnesium that are essential in the synthesis or function of neurotransmitters.) An enhanced neurochemical balance within the body and brain leads to the healing of symptoms. Supplementation can help those recovering from dependencies to achieve more balanced neurotransmitter levels and improved energy, well being, and sleep. Balancing neurotransmitter levels will also reduce anxiety, cravings, and depression.



Amino acid and vitamin therapies can rebalance neurotransmitters. The body gets amino acids from dietary protein, but that does not provide targeted supplementation, which can correct neurotransmitter deficiencies more promptly than dietary protein alone. The Passages Dependency Cure Supplement Formulas contain amino-acid and essential neurofactor supplementation designed to replenish these imbalances naturally.

1. Start Passages Serenity anytime after withdrawal from addictive substances. It will strengthen the inhibitory (or calming) side of your nervous system.
2. We recommend that Passages Replenishment also be taken after withdrawal from addictive substances and started along with Passages Serenity. Passages Replenishment supports the energy side of your nervous system and the adrenal glands. Continue both Passages Serenity and Passages Replenishment for three months, then re-assess. If your symptoms are improving (that is, you have decreased anxiety, depression, and cravings and improved sleep and energy), continue Serenity and Replenishment for six to twelve months for the best results.
3. After three months of using Passages Serenity and Replenishment, if you are still lacking energy or motivation, replace Passages Replenishment with Passages Replenishment Extreme while continuing with Passages Serenity. Stay on Passages Serenity and Passages Replenishment Extreme for six to twelve months total best results.

Check with your doctor before adding any of these supplements to your medical regimen.

You should have withdrawn from the substance you were addicted to before starting these supplements. Do not abruptly stop alcohol, benzodiazepines, or phenobarbital without direct supervision of a physician as it could be life threatening.

People on antipsychotic medications should not take these supplements.

Patients with phenylketonuria (PKU) should not take Passages Replenishment Extreme formula. PKU is a genetic disorder condition usually diagnosed in childhood that causes an inability to utilize the essential amino acid phenylalanine.

If you develop any side effects from the Passages supplements, stop them immediately and consult with your physician.